2020-05-16: The Steering Committee wrote an editorial about the impact of the COVID-19 pandemic on the APPROACH-IS II research project. Read the editorial here. 2020-03-25: The Steering Committee highly recommends to suspense recruitment/data collection due to the COVID-19 pandemic and potential risk for biased results 2020-02-26: The first info flash about APPROACH-IS II has been distributed. Read it here. 2020-01-01: Worldwide, 647 patients have been included in the study. 2019-08-01: The first patient was enrolled in the study. 2019-05-08: The number of participating centers is increasing, with currently 81 centers from 39 countries that have confirmed their participation in APPROACH-IS II. 2019-01-30: A total of 64 centers have confirmed their participation in the project, of which 14 centers are located in middle- or low-income countries. 2018-11-22: APPROACH-IS II is to be launched. Join us in this new project.